Gene Mapping is the graphic representation of the arrangement of a gene or a DNA sequence on a chromosome. Also known as linkage mapping, it is used to locate and identify the gene or group of genes that determines a particular inherited trait.
The [course_title] course teaches linkage disequilibrium mapping that helps you to analyse non-familial data. Basic concepts of genetic variations will also be discussed in the course.
Prior knowledge of statistical tests and estimation is required.
Assessment
This course does not involve any written exams. Students need to answer 5 assignment questions to complete the course, the answers will be in the form of written work in pdf or word. Students can write the answers in their own time. Each answer needs to be 200 words (1 Page). Once the answers are submitted, the tutor will check and assess the work.
Certification
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Course Credit: Kyoto University
Course Curriculum
| Module: 1 | |||
| Contents of Four Sections | 00:02:00 | ||
| Structure of Section 1 | 00:04:00 | ||
| Module: 2 | |||
| Part 1: How to Use Linkage Disequilibrium for Gene Mapping | 00:05:00 | ||
| Part 2: How is LD Measured? | 00:09:00 | ||
| Part 3: Calculation of LD index | 00:13:00 | ||
| Part 4: r^2 and D’ (LD indices) | 00:04:00 | ||
| Part 5: Parameterization of Haplotype Frequency | 00:10:00 | ||
| Part 6: Genotype from Haplotype | 00:06:00 | ||
| Part 7: Genotype Calculation with R | 00:03:00 | ||
| Part 8: Short Summary of This Section | 00:02:00 | ||
| Module: 3 | |||
| Part 1: 2×3 Table and Single SNP Association Tests | 00:21:00 | ||
| Part 2: 2×3 Data Simulation and SNP Tests with R | 00:04:00 | ||
| Module: 4 | |||
| Part 1: GWAS and Uniform Distribution of p-values | 00:12:00 | ||
| Part 2: Minimum p-value in GWAS | 00:14:00 | ||
| Part 3: Bonferroni’s Correction | 00:05:00 | ||
| Part 4: Multiple-testing Correction for Mutually Dependent Tests | 00:09:00 | ||
| Module: 5 | |||
| Part 1: Mutations and Genetic Drift | 00:13:00 | ||
| Part 2: Allele Frequency, Effect Size and Power | 00:26:00 | ||
| Message to Students Who Finish This Course | 00:03:00 | ||
| Assessment | |||
| Submit Your Assignment | 00:00:00 | ||
| Certification | 00:00:00 | ||
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