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The  [course_title] course teaches you to address the fundamental questions in modern biology through mathematical modelling techniques. You will be introduced to the general overview of modelling techniques in molecular biology and genetics, cell biology and developmental biology so that you can address the problems through mathematical reasoning. The course explains the fundamental experiments that validate mathematical models. Other topics covered in the course are molecular, cellular, and developmental systems biology, bacterial chemo taxis, genetic oscillators, control theory and genetic networks, and gradient sensing systems. Apart from these, the course teaches about constructing and modelling of genetic networks, lambda phage as a genetic switch, synthetic genetic switches, circadian rhythms, reaction-diffusion equations, local activation and global inhibition models, center finding networks, general pattern formation models, and modelling cell-cell communication, quorum sensing. Finally, the models for Drosophila development will be discussed in the course.


This course does not involve any written exams. Students need to answer 5 assignment questions to complete the course, the answers will be in the form of written work in pdf or word. Students can write the answers in their own time. Each answer needs to be 200 words (1 Page). Once the answers are submitted, the tutor will check and assess the work.


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Course Credit: MIT

Course Curriculum

Part I: Systems Microbiology
Introduction 00:45:00
Lambda Phage 01:00:00
Multistability (cont.) 01:00:00
Stability Analysis 00:15:00
Introduction E. coli Chemotaxis 01:00:00
Fine-tuned versus Robust Chemotaxis Models 00:45:00
Wrapping up Chemotaxis 00:45:00
Genetic Oscillators 00:45:00
Part II: Cell Systems Biology
Introduction Cell Systems Biology 00:45:00
Local Excitation (cont.) 00:30:00
Rapid Pole-to-pole Oscillations in E. coli (cont.) 00:45:00
Rapid Pole-to-pole Oscillations in E. coli (cont.) 00:45:00
Models for Eukaryotic Gradient Sensing (cont.) 00:45:00
Part III: Developmental Systems Biology
Quorum Sensing 00:45:00
Drosophila Development 00:45:00
Submit Your Assignment 00:00:00
Certification 00:00:00

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