The [course_title] course deals with the basic driving forces for transport. You will be introduced to these forces such as chemical gradients, electrical interactions, and fluid flow that are applied to the biology and biophysics of molecules, cells, and tissues. Emphasize will be given to the recent problems in biology, biophysics, and medicine.
The purpose of the course is to amalgamate the principles of coupling between chemical, electrical, and mechanical forces and flows inherent to tissues, membranes, macromolecules, and biomaterials.
This course does not involve any written exams. Students need to answer 5 assignment questions to complete the course, the answers will be in the form of written work in pdf or word. Students can write the answers in their own time. Each answer needs to be 200 words (1 Page). Once the answers are submitted, the tutor will check and assess the work.
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Course Credit: MIT
|Course introduction, overview, and objectives||00:30:00|
|Introduction to random processes; Boltzmann distribution and statistical thermodynamics||01:00:00|
|Diffusion as a random walk; Stokes-Einstein relation for diffusion coefficient||00:45:00|
|Constitutive equations for diffusion (Fick’s Laws); Conservation of mass for a control volume; Differential form; Steady diffusion (1D); Boundary conditions||01:00:00|
|Examples of diffusion-reaction: Diffusion of a ligand through tissue with cell receptor-ligand interactions; Diffusion-reaction kinetics||00:45:00|
|Case study IGF-1 diffusion-reaction within tissues and cell seeded scaffolds; binding to IGF binding proteins & cell surface receptors; experimental methods||01:00:00|
|E-fields and transport; Maxwell’s equations||00:45:00|
|Define electrical potential; conservation of charge; Electro-quasistatics||00:45:00|
|Laplacian solutions via Separation of Variables; Electric field boundary conditions; Ohmic transport; Charge Relaxation; Electrical migration vs. chemical diffusive fluxes||01:00:00|
|Electrochemical coupling; Electrical double layers; Poisson–Boltzmann Equation||01:00:00|
|Donnan equilibrium in tissues, gels, polyelectrolyte networks||01:00:00|
|Charge group ionization & electro-diffusion-reaction in molecular networks||00:45:00|
|Case study: Charged protein transport in charged tissues & gels; Donnan partitioning, diffusion-reaction in extracellular matrix; experimental methods||01:00:00|
|Conservation of mass and momentum in fluids; convective solute transfer||00:45:00|
|Viscous stress-strain rate relations; Navier–Stokes equations||00:45:00|
|Low Reynolds number flows; Stokes equation; Scaling and dimensional analysis||00:45:00|
|Newtonian, fully developed low Reynolds number flows||00:45:00|
|Diffusion and convection; The Peclet number; Convection-diffusion-reaction and boundary layers||00:45:00|
|Concentration boundary layers: Fully-developed flow and transport||01:00:00|
|Integrative Case Studies: Physicochemical, Mechanical, & Electrical Interactions|
|Capillary electroosmosis: Theory and experiments||00:45:00|
|MEMs, microfluidics + electrokinetics, cells and hydrogels; (with guest lecture)||01:00:00|
|This resource may not render correctly in a screen reader.Electrophoresis, chromatography and extracellular matrix biochemistry||01:00:00|
|DLVO theory: Double layer repulsion and molecular interactions (proteins, DNA, GAGs)||00:45:00|
|Porous media flows: Extracellular and intracellular||00:45:00|
|Cell / molecular electrokinetics; review of term paper project||00:45:00|
|Submit Your Assignment||00:00:00|
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