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The [course_title] course deals with the basic driving forces for transport. You will be introduced to these forces such as chemical gradients, electrical interactions, and fluid flow that are applied to the biology and biophysics of molecules, cells, and tissues. Emphasize will be given to the recent problems in biology, biophysics, and medicine.

The purpose of the course is to amalgamate the principles of coupling between chemical, electrical, and mechanical forces and flows inherent to tissues, membranes, macromolecules, and biomaterials.

Assessment

This course does not involve any written exams. Students need to answer 5 assignment questions to complete the course, the answers will be in the form of written work in pdf or word. Students can write the answers in their own time. Each answer needs to be 200 words (1 Page). Once the answers are submitted, the tutor will check and assess the work.

Certification

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Course Credit: MIT

Course Curriculum

Chemical Subsystem
Course introduction, overview, and objectives 00:30:00
Introduction to random processes; Boltzmann distribution and statistical thermodynamics 01:00:00
Diffusion as a random walk; Stokes-Einstein relation for diffusion coefficient 00:45:00
Constitutive equations for diffusion (Fick’s Laws); Conservation of mass for a control volume; Differential form; Steady diffusion (1D); Boundary conditions 01:00:00
Examples of diffusion-reaction: Diffusion of a ligand through tissue with cell receptor-ligand interactions; Diffusion-reaction kinetics 00:45:00
Case study IGF-1 diffusion-reaction within tissues and cell seeded scaffolds; binding to IGF binding proteins & cell surface receptors; experimental methods 01:00:00
Electrical Subsystem
E-fields and transport; Maxwell’s equations 00:45:00
Define electrical potential; conservation of charge; Electro-quasistatics 00:45:00
Laplacian solutions via Separation of Variables; Electric field boundary conditions; Ohmic transport; Charge Relaxation; Electrical migration vs. chemical diffusive fluxes 01:00:00
Electrochemical coupling; Electrical double layers; Poisson–Boltzmann Equation 01:00:00
Donnan equilibrium in tissues, gels, polyelectrolyte networks 01:00:00
Charge group ionization & electro-diffusion-reaction in molecular networks 00:45:00
Case study: Charged protein transport in charged tissues & gels; Donnan partitioning, diffusion-reaction in extracellular matrix; experimental methods 01:00:00
Mechanical Subsystem
Conservation of mass and momentum in fluids; convective solute transfer 00:45:00
Viscous stress-strain rate relations; Navier–Stokes equations 00:45:00
Low Reynolds number flows; Stokes equation; Scaling and dimensional analysis 00:45:00
Newtonian, fully developed low Reynolds number flows 00:45:00
Diffusion and convection; The Peclet number; Convection-diffusion-reaction and boundary layers 00:45:00
Concentration boundary layers: Fully-developed flow and transport 01:00:00
Integrative Case Studies: Physicochemical, Mechanical, & Electrical Interactions
Capillary electroosmosis: Theory and experiments 00:45:00
MEMs, microfluidics + electrokinetics, cells and hydrogels; (with guest lecture) 01:00:00
This resource may not render correctly in a screen reader.Electrophoresis, chromatography and extracellular matrix biochemistry 01:00:00
DLVO theory: Double layer repulsion and molecular interactions (proteins, DNA, GAGs) 00:45:00
Porous media flows: Extracellular and intracellular 00:45:00
Cell / molecular electrokinetics; review of term paper project 00:45:00
Assessment
Submit Your Assignment 00:00:00
Certification 00:00:00

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